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DAVID REISMAN, Ph.D.
Associate Professor, USC, Biological Sciences
DEGREES
Ph.D., 1986, University of Wisconsin, Madison
RESEARCH INTERESTS
Regulation of Expression of the p53 tumor suppressor
It is now well established that the wild-type p53 gene encodes a protein that has properties of a negative growth regulator that induces exit from the cell cycle upon damage to DNA. In many transformed cells and primary tumors, mutant p53 proteins that have lost many of p53's growth suppressing functions are detected at elevated levels. Some mutant p53 alleles may be oncogenic and contribute to the transformed phenotype. We have demonstrated that elevated transcription of the p53 gene can contributed to elevated p53 expression in tumor cells. The major goals of our research are to define the role that mutant p53 plays in transformation and to determine the mechanisms that lead to de-regulated expression of the p53 gene.
CONTACT INFORMATION
University of South Carolina | College of Arts and Sciences | Biological Sciences | Coker Life Science Building | Columbia, SC 29208 | E-mail
Office: 803 . 777 . 8108 | Fax: 803 . 777 . 4002
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