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LORNE HOFSETH, PhD
Assistant Professor of Biomedical Chemistry, USC College of Pharmacy, Department of Basic Pharmaceutical Sciences
Senior Scientific Member, South Carolina Cancer Center
Associate Member, Hollings Cancer Center, Medical University of South Carolina
DEGREES
Ph.D., 1996, Simon Fraser University, Canada
PostDoc, 1999, Michigan State University
PostDoc, 2003, National Institutes of Health
PROFESSIONAL MEMBERSHIPS
American Association for Cancer Research - Full Member
Environmental Mutagen Society
American Association of Colleges of Pharmacy
Courses Taught:
SCCP 600 Physiology/Pathophysiology I
SCCP 601 Physiology/Pathophysiology II
SCCP 717 Cancer: Causes, Treatment and Prevention
Phrm 704/705 Graduate Course Recitation
Honors, Lectures and Other Special Scientific Recognition:
1991-1992 C. N. - Terry Fox Research Fellowship in Cancer, Simon Fraser University
1992-1994 Graduate Fellowship, Simon Fraser University, Burnaby, B.C.
1997-2002 Student Mentor, Michigan State University and the National Cancer Institute
2001 Aspen Cancer Conference Young Investigator Award
2002 American Association for Cancer Research Scholar in Training Award
2003 Panel Member: Review and Future Course of the journal: Carcinogenesis
2004 Section Co-Chair, and invited speaker: Microbes and Malignancy Session; 2004 Annual Environmental Mutagen Society Meeting
2006 Invited speaker, World Cancer Research Fund-American Institute for Cancer Research Annual International Conference
2006 Researcher of the Year Award, College of Pharmacy, University of South Carolina
2007 Invited speaker: Falk International Symposium, March 23-24, Sevilla, Spain
OTHERS
Manuscript Reviewer for publications in: Gastroenterology, Cancer Research, Clinical Cancer Research, The Lancet, Journal of Biological Chemistry, Carcinogenesis, Cell Death and Differentiation, Hepatology, Gut, Molecular Pharmacology, Oncogene, The British Journal of Cancer, The International Journal of Cancer, The Journal of Hepatology, American Journal of Physiology, Molecular Pharmacology, Biochemistry and Cellular Biology.
RESEARCH SUPPORT
1. R21DK071541-01 (NIH/NIDDK) 04/01/2006-3/31/2008
Title: Nitric oxide as a target for dietary intervention in colitis.
2. P20RR17698-01 (NIH/NCRR) 07/01/07-06/30/08
Title: Center for Colon Cancer Research.
3. Clinical Trial (Contract) 1/1/2007-7/1/2008
Title: A prospective study to examine the effects of a Juice concentrate on global body inflammatory load in healthy people.
4. 1P01AT003961-01A1 (NCCAM/NI)H 12/1/2007 – 11/30/2012
Title: Center for CAM Research on Autoimmune Inflammatory Diseases.
RESEARCH INTEREST
World-wide, about 1⁄4 of human cancers are linked to chronic infection and associated inflammation. Examples include patients with inflammatory bowel disease (increased colon cancer risk), Barrett’s esophagus (high esophageal cancer risk), and hepatitis (high liver cancer risk). Currently there are two goals in my lab. First, we aim to better understand the mechanisms of inflammatory-mediated carcinogenesis through the identification of key cancer proteins and pathways (e.g. retinoblastoma, p53, DNA repair) dysregulated by free-radicals. This is done at multiple levels (cell culture, animal models of inflammation and analysis of chronically inflamed human tissues). Second, we aim to translate this into chemopreventive strategies to decrease the cancer burden in patients with these 'oxyradical overload diseases'.
CONTACT INFORMATION
USC College of Pharmacy | Room 513C, Coker Life Sciences Building | 715 Sumter Street | Columbia, SC 29208 | E-mail
Office: 803 . 777 . 2080 | Fax: 803 . 777 . 8356
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