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FRANKLIN G. BERGER, PhD Lab
LAB PERSONNEL
|
Franklin Berger, PhD |
Director of The Center for Colon Cancer
Research |
| Karen Barbour, MS |
Research Associate |
| Tia Davis, BS |
Research Specialist |
| Sangita Koli, BS |
Graduate Student |
|
John Murphy, BA |
Graduate Student |
| Meggan Pass |
Laboratory Assistant |
| Marj Peņa, PhD (web site) |
Research Assistant Professor |
|
Kenn White, BS |
Graduate Student |
| Yang Yang Xing, MS |
Research Specialist |
PUBLICATIONS
Tucker JM, Murphy JT, Kisiel N, Diegelman P, Barbour KW,
Davis C, Medda M, Alhonen L, Janne J, Kramer DL, Porter CW,
Berger FG. Potent modulation of intestinal tumorigenesis in
Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine
N1-acetyltransferase.. Cancer Res. 2005 Jun
15;65(12):5390-8.
Mehl KA, Davis JM, Clements JM, Berger FG, Pena MM, Carson
JA. Decreased intestinal polyp multiplicity is related to
exercise mode and gender in ApcMin/+ mice. J Appl Physiol.
2005 Jun;98(6):2219-25.
Miller-Lotan R, Herskowitz Y, Kalet-Litman S, Nakhoul F,
Aronson D, Zoabi R, Asaf R, Ben-Izhak O, Sabo E, Lim SK,
Baumann H, Berger FG, Levy AP. Increased renal hypertrophy
in diabetic mice genetically modified at the haptoglobin
locus. Diabetes Metab Res Rev. 2005.
Arredouani MS, Kasran A, Vanoirbeek JA, Berger FG, Baumann
H, Ceuppens JL. Haptoglobin dampens endotoxin-induced
inflammatory effects both in vitro and in vivo. Immunology.
2005 Feb;114(2):263-71
Murphy JT, Tucker JM, Davis C, Berger FG. Raltitrexed
Increases Tumorigenesis as a Single Agent Yet Exhibits
Anti-Tumor Synergy with 5-Fluorouracil in Apc(Min/+)
Mice(1). Cancer Biol Ther. 2004 Nov 2;3(11)
Berger FG. The interleukin-6 gene: a susceptibility factor
that may contribute to racial and ethnic disparities in
breast cancer mortality. Breast Cancer Res Treat. 2004
Dec;88(3):281-5.
Berger SH, Berger FG, Lebioda L. Effects of ligand binding
and conformational switching on intracellular stability of
human thymidylate synthase. Biochim Biophys Acta. 2004 Jan
14;1696(1):15-22.
Forsthoefel AM, Pena MM, Xing YY, Rafique Z, Berger FG.
Structural determinants for the intracellular degradation of
human thymidylate synthase. Biochemistry. 2004 Feb
24;43(7):1972-9.
Hochepied T, Berger FG, Baumann H, Libert C.alpha(1)-Acid
glycoprotein: an acute phase protein with inflammatory and
immunomodulating properties. Cytokine Growth Factor Rev.
2003 Feb;14(1):25-34.
Yang F, Haile DJ, Berger FG, Herbert DC, Van Beveren E, Ghio
AJ. Haptoglobin reduces lung injury associated with exposure
to blood. Am J Physiol Lung Cell Mol Physiol. 2003
Feb;284(2):L402-9.
Barbour KW, Wei F, Brannan C, Flotte TR, Baumann H, Berger
FG. The murine alpha(1)-proteinase inhibitor gene family:
polymorphism, chromosomal location, and structure. Genomics.
2002 Nov;80(5):515-22.
Tolosano E, Fagoonee S, Hirsch E, Berger FG, Baumann H,
Silengo L, Altruda F. Enhanced splenomegaly and severe liver
inflammation in haptoglobin/hemopexin double-null mice after
acute hemolysis. Blood. 2002 Dec 1;100(12):4201-8.
Tucker JM, Davis C, Kitchens ME, Bunni MA, Priest DG,
Spencer HT, Berger FG. Response to 5-fluorouracil
chemotherapy is modified by dietary folic acid deficiency in
Apc(Min/+) mice. Cancer Lett. 2002 Dec 10;187(1-2):153-62.
Hochepied T, Wullaert A, Berger FG, Baumann H, Brouckaert P,
Steidler L, Libert C. Overexpression of alpha(1)-acid
glycoprotein in transgenic mice leads to sensitisation to
acute colitis. Gut. 2002 Sep;51(3):398-404.
Barbour KW, Goodwin RL, Guillonneau F, Wang Y, Baumann H,
Berger FG. Functional diversification during evolution of
the murine alpha(1)-proteinase inhibitor family: role of the
hypervariable reactive center loop. Mol Biol Evol. 2002
May;19(5):718-27.
Wang Y, Kinzie E, Berger FG, Lim SK, Baumann H. Haptoglobin,
an inflammation-inducible plasma protein. Redox Rep.
2001;6(6):379-85.
Barbour KW, Davis T, White A, Baumann H, Berger FG.
Haptoglobin, inflammation, and tumorigenesis in the MIN
mouse. Redox Rep. 2001;6(6):366-8.
Barker C, Barbour KW, Berger FG, Hajduk SL. Activity of
human trypanosome lytic factor in mice. Mol Biochem
Parasitol. 2001 Oct;117(2):129-36.
Barker C, Barbour KW, Berger FG, Hajduk SL. Activity of
human trypanosome lytic factor in mice. Mol Biochem
Parasitol. 2001 Oct;117(2):129-36.
Shaw D, Berger FG, Spencer HT. Retroviral expression of
Escherichia coli thymidylate synthase cDNA confers
high-level antifolate resistance to hematopoietic cells. Hum
Gene Ther. 2001 Jan 1;12(1):51-9.
Hochepied T, Van Molle W, Berger FG, Baumann H, Libert C.
Involvement of the acute phase protein alpha 1-acid
glycoprotein in nonspecific resistance to a lethal
gram-negative infection. J Biol Chem. 2000 May
19;275(20):14903-9.
Fantz C, Shaw D, Jennings W, Forsthoefel A, Kitchens M, Phan
J, Minor W, Lebioda L, Berger FG, Spencer HT. Drug-resistant
variants of Escherichia coli thymidylate synthase: effects
of substitutions at Pro-254. Mol Pharmacol. 2000
Feb;57(2):359-66.
Kitchens ME, Forsthoefel AM, Barbour KW, Spencer HT, Berger
FG. Mechanisms of acquired resistance to thymidylate
synthase inhibitors: the role of enzyme stability. Mol
Pharmacol. 1999 Nov;56(5):1063-70.
Persson K, Heby O, Berger FG. The functional intronless S-adenosylmethionine
decarboxylase gene of the mouse (Amd-2) is linked to the
ornithine decarboxylase gene(Odc) on chromosome 12 and is
present in distantly related species of the genus Mus. Mamm
Genome. 1999 Aug;10(8):784-8.
Libert C, Hochepied T, Berger FG, Baumann H, Fiers W,
Brouckaert P. High-level constitutive expression of alpha
1-acid glycoprotein and lack of protection against tumor
necrosis factor-induced lethal shock in transgenic mice.
Transgenic Res. 1998 Nov;7(6):429-35.
Kitchens ME, Forsthoefel AM, Rafique Z, Spencer HT, Berger
FG. Ligand-mediated induction of thymidylate synthase occurs
by enzyme stabilization. Implications for autoregulation of
translation. J Biol Chem. 1999 Apr 30;274(18):12544-7.
Singh N, Berger FG. Evolution of a mammalian promoter
through changes in patterns of transcription factor binding.
J Mol Evol. 1999 Feb;48(2):252.
Singh N, Berger FG. Evolution of a mammalian promoter
through changes in patterns of transcription factor binding.
J Mol Evol. 1998 Jun;46(6):639-48.
Singh N, Barbour KW, Berger FG. Evolution of transcriptional
regulatory elements within the promoter of a mammalian gene.
Mol Biol Evol. 1998 Mar;15(3):312-25.
Reilly RT, Forsthoefel AM, Berger FG. Functional effects of
amino acid substitutions at residue 33 of human thymidylate
synthase. Arch Biochem Biophys. 1997 Jun 15;342(2):338-43.
Goodwin RL, Barbour KW, Berger FG. Expression of the alpha
1-proteinase inhibitor gene family during evolution of the
genus Mus. Mol Biol Evol. 1997 Apr;14(4):420-7.
Goodwin RL, Baumann H, Berger FG. Patterns of divergence
during evolution of alpha 1-proteinase inhibitors in
mammals. Mol Biol Evol. 1996 Feb;13(2):346-58.
Reilly RT, Barbour KW, Dunlap RB, Berger FG. Biphasic
binding of 5-fluoro-2'-deoxyuridylate to human thymidylate
synthase. Mol Pharmacol. 1995 Jul;48(1):72-9.
Asadi FK, Dimaculangan DD, Berger FG. Androgen regulation of
gene expression in primary epithelial cells of the mouse
kidney. Endocrinology. 1994 Mar;134(3):1179-87.
Rheaume C, Goodwin RL, Latimer JJ, Baumann H, Berger FG.
Evolution of murine alpha 1-proteinase inhibitors: gene
amplification and reactive center divergence. J Mol Evol.
1994 Feb;38(2):121-31.
Pajovic S, Jones VE, Prowse KR, Berger FG, Baumann H.
Species-specific changes in regulatory elements of mouse
haptoglobin genes. J Biol Chem. 1994 Jan 21;269(3):2215-24.
Hughey CT, Barbour KW, Berger FG, Berger SH. Functional
effects of a naturally occurring amino acid substitution in
human thymidylate synthase. Mol Pharmacol. 1993
Aug;44(2):316-23.
Johannes GJ, Berger FG. Domains within the mammalian
ornithine decarboxylase messenger RNA have evolved
independently and episodically. J Mol Evol. 1993
Jun;36(6):555-67.
Hughey CT, Barbour KW, Berger FG, Berger SH. Genetic
variation in thymidylate synthase confers resistance to
5-fluorodeoxyuridine. Adv Exp Med Biol. 1993;339:67-76.
Kass DH, Berger FG, Dawson WD. The evolution of coexisting
highly divergent LINE-1 subfamilies within the rodent genus
Peromyscus. J Mol Evol. 1992 Dec;35(6):472-85.
Barbour KW, Hoganson DK, Berger SH, Berger FG. A naturally
occurring tyrosine to histidine replacement at residue 33 of
human thymidylate synthase confers resistance to
5-fluoro-2'-deoxyuridine in mammalian and bacterial cells.
Mol Pharmacol. 1992 Aug;42(2):242-8.
Johannes G, Berger FG. Alterations in mRNA translation as a
mechanism for the modification of enzyme synthesis during
evolution. The ornithine decarboxylase model. J Biol Chem.
1992 May 15;267(14):10108-15.
Chaudhuri A, Barbour KW, Berger FG. Evolution of messenger
RNA structure and regulation in the genus Mus: the
androgen-inducible RP2 mRNAs. Mol Biol Evol. 1991
Sep;8(5):641-53.
Mackiewicz A, Dewey MJ, Berger FG, Baumann H. Acute phase
mediated change in glycosylation of rat alpha 1-acid
glycoprotein in transgenic mice. Glycobiology. 1991
Jun;1(3):265-9.
Rhee M, Dimaculangan D, Berger FG. Androgen modulation of
DNA-binding factors in the mouse kidney. Mol Endocrinol.
1991 Apr;5(4):564-72.
Dewey MJ, Rheaume C, Berger FG, Baumann H. Inducible and
tissue-specific expression of rat alpha-1-acid glycoprotein
in transgenic mice. J Immunol. 1990 Jun 1;144(11):4392-8.
Barbour KW, Berger SH, Berger FG. Single amino acid
substitution defines a naturally occurring genetic variant
of human thymidylate synthase. Mol Pharmacol. 1990
Apr;37(4):515-8.
Latimer JJ, Berger FG, Baumann H. Highly conserved upstream
regions of the alpha 1-antitrypsin gene in two mouse species
govern liver-specific expression by different mechanisms.
Mol Cell Biol. 1990 Feb;10(2):760-9.
Berger FG. Assignment of a gene encoding ornithine
decarboxylase to the proximal region of chromosome 12 in the
mouse. Biochem Genet. 1989 Dec;27(11-12):745-53.
Nadeau JH, Berger FG, Cox DR, Crosby JL, Davisson MT,
Ferrara D, Fuchs E, Hart C, Hunihan L, Lalley PA, et al. A
family of type I keratin genes and the homeobox-2 gene
complex are closely linked to the rex locus on mouse
chromosome 11. Genomics. 1989 Oct;5(3):454-62.
Rheaume C, Schonfeld C, Porter C, Berger FG. Evolution of
androgen-regulated ornithine decarboxylase expression in
mouse kidney. Mol Endocrinol. 1989 Aug;3(8):1243-51.
Rheaume C, Barbour KW, Tseng-Crank J, Berger FG. Molecular
genetics of androgen-inducible RP2 gene transcription in the
mouse kidney. Mol Cell Biol. 1989 Feb;9(2):477-83.
Berger FG, Watson G. Androgen-regulated gene expression.
Annu Rev Physiol. 1989;51:51-65.
Rheaume C, Latimer JJ, Baumann H, Berger FG. Tissue- and
species-specific regulation of murine alpha 1-antitrypsin
gene transcription. J Biol Chem. 1988 Oct
15;263(29):15118-21.
Berger SH, Barbour KW, Berger FG. A naturally occurring
variation in thymidylate synthase structure is associated
with a reduced response to 5-fluoro-2'-deoxyuridine in a
human colon tumor cell line. Mol Pharmacol. 1988
Oct;34(4):480-4.
Berger SH, Berger FG. Thymidylate synthase as a determinant
of 5-fluoro-2'-deoxyuridine response in human colonic tumor
cell lines. Mol Pharmacol. 1988 Oct;34(4):474-9.
Tseng-Crank J, Schonfeld C, Berger FG. Evolution of
androgen-regulated mRNA expression in mouse kidney. Mol Biol
Evol. 1988 Jul;5(4):442-54.
Barbour KW, Berger SH, Berger FG, Thompson EA Jr.
Glucocorticoid regulation of the genes encoding thymidine
kinase, thymidylate synthase, and ornithine decarboxylase in
P1798 cells. Mol Endocrinol. 1988 Jan;2(1):78-84.
Berger SH, Davis ST, Barbour KW, Berger FG. The role of
thymidylate synthase in the response to
fluoropyrimidine-folinic acid combinations. Adv Exp Med
Biol. 1988;244:59-69.
Latimer JJ, Berger FG, Baumann H. Developmental expression,
cellular localization, and testosterone regulation of alpha
1-antitrypsin in Mus caroli kidney. J Biol Chem. 1987 Sep
15;262(26):12641-6.
Tseng-Crank J, Berger FG. Evolution of steroid-inducible RP2
mRNA expression in the mouse kidney. Genetics. 1987
Aug;116(4):593-9.
Clark JL, Berger SH, Mittelman A, Berger FG. Thymidylate
synthase gene amplification in a colon tumor resistant to
fluoropyrimidine chemotherapy. Cancer Treat Rep. 1987
Mar;71(3):261-5.
Porter CW, Berger FG, Pegg AE, Ganis B, Bergeron RJ.
Regulation of ornithine decarboxylase activity by spermidine
and the spermidine analogue N1N8-bis(ethyl)spermidine.
Biochem J. 1987 Mar 1;242(2):433-40.
Nadeau JH, Berger FG, Kelley KA, Pitha PM, Sidman CL,
Worrall N. Rearrangement of genes located on homologous
chromosomal segments in mouse and man: the location of genes
for alpha- and beta-interferon, alpha-1 acid glycoprotein-1
and -2, and aminolevulinate dehydratase on mouse chromosome
4. Genetics. 1986 Dec;114(4):1239-55.
Berger FG, Porter CW. Putrescine does not mediate the
androgen-response in mouse kidney. Biochem Biophys Res
Commun. 1986 Jul 31;138(2):771-7.
Berger FG, Loose D, Meisner H, Watson G. Androgen induction
of messenger RNA concentrations in mouse kidney is
posttranscriptional. Biochemistry. 1986 Mar 11;25(5):1170-5.
Berger SH, Jenh CH, Johnson LF, Berger FG. Thymidylate
synthase overproduction and gene amplification in
fluorodeoxyuridine-resistant human cells. Mol Pharmacol.
1985 Nov;28(5):461-7.
Berger FG, Baumann H. An evolutionary switch in
tissue-specific gene expression. Abundant expression of
alpha 1-antitrypsin in the kidney of a wild mouse species. J
Biol Chem. 1985 Jan 25;260(2):1160-5.
Baumann H, Berger FG. Genetics and evolution of the acute
phase proteins in mice. Mol Gen Genet. 1985;201(3):505-12.
Berger FG, Szymanski P, Read E, Watson G. Androgen-regulated
ornithine decarboxylase mRNAs of mouse kidney. J Biol Chem.
1984 Jun 25;259(12):7941-6.
Baumann H, Held WA, Berger FG. The acute phase response of
mouse liver. Genetic analysis of the major acute phase
reactants. J Biol Chem. 1984 Jan 10;259(1):566-73.
Berger FG. Studies on genetic variation in major urinary
protein synthesis in mouse liver. Biochem Genet. 1983
Feb;21(1-2):15-23.
Elliott RW, Berger FG. DNA sequence polymorphism in an
androgen-regulated gene is associated with alteration in the
encoded RNAs. Proc Natl Acad Sci U S A. 1983
Jan;80(2):501-4.
Berger FG, Szoka P. Biosynthesis of the major urinary
proteins in mouse liver: a biochemical genetic study.
Biochem Genet. 1981 Dec;19(11-12):1261-73.
Berger FG, Gross KW, Watson G. Isolation and
characterization of a DNA sequence complementary to an
androgen-inducible messenger RNA from mouse kidney. J Biol
Chem. 1981 Jul 10;256(13):7006-13.
Berger FG, Paigen K. Cis-active control of mouse
beta-galactosidase biosynthesis by a systemic regulatory
locus. Nature. 1979 Nov 15;282(5736):314-6.
Berger FG, Breen GA, Paigen K. Genetic determination of the
developmental program for mouse liver beta-galactosidase:
involvement of sites proximate to and distant from the
structural gene. Genetics. 1979 Aug;92(4):1187-203.
Berger FG, Lusis AJ. Relationship between genetic variation
in thermal stability and electrophoretic mobility of mouse
beta-galactosidase. Biochem Genet. 1978
Oct;16(9-10):1007-14.
Berger FG, Paigen K. Regulation of the rate of
beta-galactosidase synthese by the Bgs and Bgt loci in the
mouse. J Biol Chem. 1978 Aug 10;253(15):5280-2.
Berger FG, Herrmann KM. Tryptophan synthetase alpha(5.7-S):
novel molecular species formed within Escherichia coli. J
Bacteriol. 1975 Nov;124(2):800-9.
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