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LORNE HOFSETH, PhD Lab
LAB PERSONNEL
Lorne J. Hofseth, Ph.D. Principal Investigator
Anne Bailey, B.Sc. Senior Technician
Venkata Kotakadi, Ph.D. Postdoc
Yu Jin, M.D. Ph.D. Student
PERSONAL PERSONNEL
Lorne's daughters, Reagan, Jenna and Tance.
PUBLICATIONS
1. Ying L, Hofseth AB, Browning DD, Nagarkatti M, Nagarkatti PS, and Hofseth LJ. Nitric oxide inactivates the retinoblastoma pathway in chronic inflammation. Cancer Research, in press.
2. Daguise VG, Burch JB, Horner MJ, Mosley C, Hofseth LJ, Wargovich MJ, Lloyd SC, Hebert JR. Colorectal cancer disparities in South Carolina: descriptive epidemiology, screening, special programs, and future direction. J S C Med Assoc. 102:177-181, 2007.
3. Hofseth LJ. Can ginseng defuse weapons of mass inflammation? Healthy Aging, December Issue, 2006.
4. Ying L and Hofseth LJ. An emerging role for endothelial nitric oxide synthase in inflammation and cancer. Cancer Research, 67:1407-10, 2007.
5. Prueitt RL, Boersma BJ, Howe TM, Goodman JE, Thomas DD, Ying L, Pfiester CM, Yfantis HG, Cottrell JR, Lee DH, Remaley AT, Hofseth LJ, Wink DA, and Ambs S. Inflammation and IGF-I Activate the Akt Pathway in Breast Cancer. International Journal of Cancer, 120:796-805, 2007.
6. Hofseth LJ and Wargovich MJ. Inflammation, Cancer, and Targets of Ginseng. J. Nutrition, 137:183S-5S, 2007.
7. Hofseth LJ and Ying L. Identifying and defusing weapons of mass inflammation in carcinogenesis. Biochimica et Biophysica Acta – Reviews on Cancer 1765: 74-84, 2006.
8. Staib, F, Robles, AI, Varticovskic, L, Wang, XW, Zeeburg, BR, Sirotin, M, Zhurkin, VB, Hofseth, LJ, Hussain, SP, Weinstein, JN, Galle, PR, Harris, CC. The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress. Cancer Research 65: 10255-10264, 2005.
9. Horner M-JD, Daguis VG, Mosley C, Johnson MG, Hofseth LJ, Wargovich MJ, Hebert JR. Colorectal cancer disparities in South Carolina: early detection, special programs, and descriptive epidemiology. Journal of the South Carolina Medical Association 101: 207-211, 2005.
10. Ying, L, Marino, J, Hussain, SP, Khan, MA, You, S, Hofseth, AB, Trivers, GE, Dixon, DA, Harris, CC, Hofseth, LJ. Chronic inflammation promotes retinoblastoma protein hyperphosphorylation and E2F1 activation. Cancer Research 65: 9132-9136, 2005.
11. Hofseth LJ, Robles AI, Espey MG, and Harris CC. Nitric oxide is a signaling molecule that regulates gene expression. Methods in Enzymology 396: 326-340, 2005.
12. Hussain, SP, Trivers, GE, Hofseth, LJ, He, P, Shaikh, I, Mechanic, LE, Doja, S, Jiang, W, Subleski, J, Shorts, L, Haines, D, Laubach, VE, Wiltrout, RH, Djurickovic, D, Harris, CC. Nitric oxide, a mediator of inflammation, suppresses tumorigenesis.Cancer Research 64: 6849-6853, 2004.
13. Hofseth, LJ., Sawa, T, Hussain, SP and Harris, CC. Inducible nitric oxide synthases as a target for chemoprevention. In: KelloffIn: Cancer Chemoprevention Volume 1: Promising Cancer Chemopreventive Agents. Humana Press, , G. L., Hawk, E. T. and Sigman, C. C. (Eds), pp. 133-152, 2004.
14. Hofseth LJ. The adaptive imbalance to genotoxic stress: genome guardians rear their ugly heads. Carcinogenesis 25: 1787-93, 2004.
15. Thomas, DD, Espey, MG, Ridnour, LA, Hofseth, LJ, Mancardi, D, Harris, CC and Wink, DA. HIF-1α, ERK and p53 are regulated by distinct threshold nitric oxide concentrations in human breast MCF7 cells. Proceedings of the National Academy of Sciences 101: 8894-8899, 2004.
16. Hofseth LJ, Robles AI, Yang Q, Wang XW, Hussain SP, and Harris CC. p53. At the crossroads of molecular carcinogenesis and molecular epidemiology. Chest 125: 83S-5S, 2004.
17. Li, C-Q, Robles, AI, Hanigan, CL, Hofseth, LJ, Trudel, LJ, Harris, CC and Wogan, GN. Apoptotic signaling pathways induced by nitric oxide in human lympohblastoid cells expressing wild-type and mutant p53. Cancer Research 64: 3022-3029, 2004.
18. . Kim, JW, Ye, Q, Forgues, M, Chen, Y, Budhu, A, Sime, J, Hofseth, LJ, Kaul, R, Wang, XW. Cancer-associated molecular signature in the tissue samples of patients with cirrhosis. Hepatology 39: 518-527, 2004.
19. Hofseth LJ, Hussain SP, Harris CC. p53. 25 years after its discovery. Trends in Pharmacological Sciences 25: 177-181, 2004.
20. Hussain, SP, Amstad, P, He, P, Robles, A, Lupold, S, Kaneko, I, Ichimiya, M, Sengupta, S, Mechanic, L, Okamura, S, Hofseth, LJ, Moake, M, Nagashima, M, Forrester, KS, Harris, CC. p53-induced upregulation of MnSOD and GPx, but not catalase increases oxidative stress and apoptosis. Cancer Research 64: 2050-2056, 2004.
21. Goodman JE, Hofseth LJ, Hussain SP, and Harris CC. Nitric oxide and p53 in cancer-prone chronic inflammation and oxyradical overload disease. Environmental and Molecular Mutagenesis 44: 3-9, 2004.
22. Zurer, I, Hofseth, LJ, Cohen, Y, Xu-Welliver, M, Hussain, SP, Harris, CC and Rotter, V. The role of p53 in base excision repair following genotoxic stress. Carcinogenesis 25: 11-19, 2004.
23. Hussain SP, Hofseth LJ, Harris CC. Radical causes of cancer. Nature - Cancer Reviews 3: 276-285, 2003.
24. Hofseth, LJ, Hussain, SP, Wogan, GN, and Harris, CC. Nitric oxide in cancer and chemoprevention. Free Radical Biology and Medicine 34: 955-968, 2003.
25. Hofseth, LJ, Khan, MA, Ambrose, M, Nikolayeva, O, Xu-Welliver, M, Kartalou, M, Hussain, SP, Roth, RB, Zhou, X, Mechanic, LE, Zurer, I, Rotter, V, Samson, LD, Harris, CC. The adaptive imbalance in base excision repair enzymes generates microsatellite instability in chronic inflammation. Journal of Clinical Investigation 112: 1887-1894, 2003.
26. Staib, F, Hussain, SP, Hofseth, LJ, Wang, XW, and Harris, CC. TP53 and liver carcinogenesis. Human Mutation 21: 201-216, 2003.
27. Hofseth, LJ, Hussain, SP, Wang, XW and Harris, CC. Hepatocellular cancers: molecular biology and genetics. In: Principles and Practices of Gastrointestinal Oncology. Lipincott, Williams and Wilkins, Phil., PA. Kelsen, D. P., Daly, J., Levin, B., Tepper, J. and Kern, S. (Eds), pp. 539-558, 2002.
28. Linke, SP, Sengupta, S, Khabie, N, Jeffries, BA, Buchhop, S, Miska, S, Henning, W, Pedeux, R, Wang, XW, Hofseth, LJ, Yang, Q, Garfield, S, Sturzbecher, H-W, Harris, CC. p53 interacts with hRAD51 and hRAD54, and directly modulates homologous recombination. Cancer Research 63: 2596-2605, 2003.
29. Hofseth, LJ, Saito, S, Hussain, SP, Espey, MG, Miranda, KM, Araki, Y, Jhappan, C, Higashimoto, Y, He, P, Linke, SP, Quezado, MM, Zurer, I, Rotter, V, Wink, DA, Appella, E and Harris, CC. Nitric oxide-induced cellular stress and p53 activation in chronic inflammation. Proceedings of the National Academy of Sciences 100: 143-148, 2003.
30. Haslam, SZ., Osuch, JR, Raafat, AM, and Hofseth, LJ. Postmenopausal hormone replacement therapy: effects on normal mammary gland in humans and in a mouse postmenopausal model. Journal of Mammary Gland Biology and Neoplasia 7: 93-105, 2002.
31. Wang, XW, Hussain, SP, Huo, T, Wu, CG, Forgues, M, Hofseth, LJ, Brechot, C and Harris, CC. Molecular pathogenesis of human hepatocellular carcinoma. Toxicology 181-182: 43-7, 2002.
32. Hussain, SP, Amstad, P, Raja, K, Sawyer, M, Hofseth, L, Shields, PG, Hewer, A, Phillips, DH, Ryberg, D, Haugen, A and Harris, CC. Mutability of p53 hotspots codons to Benzo(a)pyrene Diol Eposide (BPDE) and the frequency of p53 mutations in nontumorous human lung. Cancer Research 61: 6350-6355, 2001.
33. Hussain, SP, Hofseth, LJ and Harris, CC. Tumor suppressor genes: at the crossroads of molecular carcinogenesis, molecular epidemiology and human risk assessment. Lung Cancer 34: S7-S15, 2001.
34. Rafaat, AR, Hofseth L.J, and Haslam, SZ. Proliferative responses to long-term estrogen and estrogen plus progesterone replacement therapy in the postmenopausal mouse mammary gland. American Journal of Obstetrics and Gynecology 184: 340-349, 2001.
35. Hussain, SP, Hofseth, LJ, Shields, PG and Harris, CC. Gene-Environment Interactions in Human Cancer Risk. In: Molecular Genetic Basis of Cancer. Lung, M. P. and Hsiao, W. L. W. (Eds), pp. 294-308, 2001.
36. Rafaat, AR, Li, S, Bennet, JM, Hofseth, LJ, Haslam, SZ. Estrogen and estrogen plus progestin act directly on the mammary gland to increase proliferation in a postmenopausal mouse model. Journal Cell Physioliology 187: 81-89, 2001.
37. Hussain, SP, Raja, K, Amstad, PA, Sawyer, M, Trudel, LJ, Wogan, GN, Hofseth, LJ, Shields, PG, Billiar, TR, Trautwein, C, Höhler, T, Galle, PR, Phillips, DH, Markin, R, Marrogi, AJ, Harris, CC. Increased p53 mutation load in nontumorous human liver of Wilson disease and hemochromatosis: Oxyradical overload diseases. Proceedings of the National Academy of Sciences 97: 12770-12775, 2000.
38. Zhou, X, Espey, MG, Chen, JX, Hofseth, LJ, Miranda, KM, Hussain, SP, Wink, DA, Harris, CC. Inhibitory effects of nitric oxide and nitrosative stress on dopamine-B-hydroxylase. Journal of Biological Chemistry 275: 21241-21246, 2000.
39. Rafaat, AM, Hofseth, LJ, Li, SJ, Bennett, JM and Haslam, SZ. A mouse model to study the effects of hormone replacement therapy on normal mouse mammary gland: enhanced proliferative response to estrogen in late postmenopausal mice. Endocrinology 140: 2570-2580, 1999.
40. Rosin, MP and Hofseth, LJ. Schistosomiasis and its association with bladder and colon cancer. In: Microbes and Malignancy: Infection as a Cause of Cancer, Oxford University Press, Parsonnet, J. and Horning, S. (Eds.), pp. 313-345, 1999.
41. Hofseth, LJ, Rafaat, AM, Osuch, JR, Pathak, DR, Slomski, CA and Haslam, SZ. Hormone replacement therapy with estrogen or estrogen plus medroxyprogesterone acetate is associated with increased epithelial proliferation in the normal postmenopausal breast. Journal of Clinical Endocrinology and Metabolism 84: 4559-4565, 1999.
42. Hofseth, LJ, Tsang, S-S and Rosin, MP. Rejoining of DNA double strand breaks after the introduction of chromosome 11 into a radiosensitive bladder carcinoma cell line. Mutation Research DNA Repair 383: 21-30, 1997.
43. Hofseth, LJ, Dunn, BP and Rosin, MP. Micronucleus frequencies in urothelial cells of catheterized patients with chronic bladder inflammation. Mutation Research 352: 65-72, 1996.
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