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PHILLIP J. BUCKHAULTS, PhD  Lab

PAST PERSONNEL
Hampton Crimm, MS, 2002-2005 (Medical Student, Uniformed Services University of the Health Sciences)
Beth Neilson, MS, 2002-2003 (Medical Student, University of South Carolina School of Medicine)
Summer Students: Blake Butler, 2004 (Undergraduate, Auburn University); Peter Miller, 2004 (Medical Student, Tel Aviv, Israel); Dora Oroian, 2005 (Undergraduate, Washington University)

PATENTS (U.S.)

Buckhaults, P., Kinzler, K. W., and Vogelstein, B.
Secreted and Cell-surface Genes Expressed in Benign and Malignant Colorectal Tumors.

Gurulingappa, H., Buckhaults, P., Kumar, S., Kinzler, K., Vogelstein, B., Kahn, S. Design, Synthesis and Evaluation of New RDP Inhibitors.

PENDING:
Shih I-M, Buckhaults P, and Zhang Z. Identifying Tumor Origin Using a Gene Expression Based Classification Map (JHU Ref 4235)

PUBLICATIONS

Castle, S., Buckhaults, P., Baldwin, L., McKenney, J.D., and Castle, R.N.(1987) The Synthesis of Monomethoxy[1]benzythienol-2,3-c]quinolines J. Heterocyclic Chem. 24:1103-1107.

Shoreibah, M., Perng, G.S., Adler, B., Weinstein, J., Basu, R., Cupples, R., Wen, D., Browne, J.K., Buckhaults, P., Fregien, N., and Pierce, M. (1993) Isolation, characterization, and expression of a cDNA encoding
N-acetylglucosaminyltransferase V. J Biol Chem 268(21):15381-15385

Paper was chosen as cover art - Cancer Research, July 15, 2003.

Lee, J.K., Buckhaults, P., Wilkes, C., Teilhet, M., King, M.L., Moremen, K.W., Pierce, M. (1997) Cloning and expression of a Xenopus laevis oocyte lectin and characterization of its mRNA levels during early development Glycobiology 7(3):367-372

Buckhaults, P., Chen, L., Fregien, N., Pierce, M. (1997) Transcriptional regulation of N-acetylglucosaminyltransferase V by the src oncogene J Biol Chem 272(31):19575-19581

Pierce, M., Buckhaults, P., Chen, L., Fregien, N. (1997) Regulation of N-acetylglucosaminyltransferase V and Asn-linked oligosaccharide b(1,6) branching by a growth factor signaling pathway and effects on cell adhesion and metastatic potential Glycoconj J 14(5):623-630

Zhou, S., Buckhaults, P., Zawel, L., Bunz, F., Riggins, G., Le Dai J., Kern, S.E., Kinzler, K.W., Vogelstein, B. (1998) Targeted deletion of Smad4 shows it is required for transforming growth factor  and activin signaling in colorectal cancer cells Proc Natl Acad Sci U S A 95(5):2412-2416

Zawel, L., Le Dai J., Buckhaults, P., Zhou, S., Kinzler, K.W., Vogelstein, B.V., Kern, S.E. (1998) Human Smad3 and Smad4 are sequence-specific transcription activators Mol Cell 1:611-617

Buckhaults, P., Rago, C., St. Croix, B., Romans, K.E., Saha, S., Zhang, L., Vogelstein, B., Kinzler, K.W. (2001) Secreted and Cell Surface Genes Expressed in Benign and Malignant Colorectal Tumors.  Cancer Research  61(19):6996-7001

Saha, S., Bardelli, A., Buckhaults, P., Velculescu, V., Rago, C., St.Croix, B., Romans, K.E., Choti, M.A., Lengauer, C.L., Kinzler, K.W., Vogelstein, B. (2001) A Phosphatase Associated with Metastasis of Colorectal Cancer.  Science 294(5545):1343-1346

Gurulingappa, H., Buckhaults, P., Vogelstein, B., Kinzler, K., Kahn, S.  (2002) Synthesis and Kinetic analysis of Renal Dipeptidase Inhibitors. Tetrahedron Letters 44 (9):1871-1873.

Buckhaults, P., Zhang, Z., Chen, Y-C., Wang, T., St. Croix, B., Saha, S., Bardelli, A., Morin, P., Polyak, K., Hruban, R., Velculescu, V., Shih, I-M. (2003). Identifying Tumor Origin Using a Gene Expression Based Classification Map.  Cancer Research 63 (14):4144-4149.

Brown, D., Ward, R., Buckhaults, P., Liu T., Romans, K., Hawkins, N., Bauskin, A., Kinzler, K., Vogelstein, B., Breit, S. (2003).  MIC-1 serum levels and genotype: associations with progress and prognosis of colorectal carcinoma.  Clinical Cancer Research. 9 (7):2642-2650.

Koopman, J., Buckhaults, P., Brown, D., Zahurak,  M., Sato, N., Sokoll, L., Chan, D., Yeo, C., Hruban, R., Breit, S., Kinzler, K., Vogelstein, B., Goggins, M. (2004) Serum Macrophage Inhibitory Cytokine 1 as a Marker of Pancreatic and other Periampullary Cancers. Clinical Cancer Research 10 (7):2386-92.

Nanda, A., Buckhaults, P., Seaman, S., Boutin, P., Shankara, S., Nacht, M., Teicher, B., Stampfl, J., Singh, S., Vogelstein, B., Kinzler, K., St.Croix, B. (2004) Identification of a Binding Partner for the Endothelial Cell Surface Proteins TEM7 and TEM7R. Cancer Research. 64 (23):8507-11.

Meeh, P. F., King, Michelle, O’Briend, R. L., Muga, S., Buckhaults, P.J., Neuberg, R., Lamb, L.S. (2006)  Characterization of the cd T cell response to acute leukemia.  Cancer Immunol Immunother  55: 1072–1080

Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber T, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE.  The Consensus Coding Sequences of Human Breast and Colorectal Cancers. Science. 2006 Sep 7; [Epub ahead of print] PMID: 16959974

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