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PAUL THOMPSON, Ph.D.
DeLaBarre
B., Thompson P.R., Wright G.D., and Berghuis A.M. Crystal
structures of homoserine dehydrogenase suggest a novel
catalytic mechanism for oxidoreductases. Nature Struct.
Biol. 2000; 7: 238-244.
Thompson P.R., Boehr D.D., and Wright G.D.
Molecular mechanism of aminoglycoside antibiotic kinase
APH(3')-IIIa: Roles of conserved active site residues. J.
Biol. Chem. 2001; 276: 23929-23936.
Thompson P.R. and Cole P.A. Probing the
mechanism of enzymatic phosphoryl transfer with a chemical
trick. Proc. Natl. Acad. Sci. USA 2001; 98: 8170-8171.
Thompson P.R., Kurooka H., Nakatani Y.,
and Cole, PA. Transcriptional coactivator protein p300:
Kinetic characterization of its histone acetyltransferase
activity. J. Biol. Chem. 2001; 276: 33721-33729.
Thompson P.R., Boehr DD, Berghuis AM,
Wright, GD. Mechanism of aminoglycoside antibiotic kinase
APH(3')-IIIa: role of the nucleotide positioning loop.
Biochemistry 2002; 41: 7001-7007.
Cebrat M., Kim C.M., Thompson P.R.,
Daugherty M., and Cole P.A. Synthesis and analysis of
potential prodrugs of coenzyme A analogues for the
inhibition of the histone acetyltransferase p300. Bioorganic
Medicinal Chemistry 2003; 31: 3307-3313.
Thompson P.R., Wang D., Wang L., Fulco
M., Pediconi N., Zhang D., An W., Ge Q., Roeder R.G., Wong
J., Levrero M., Sartorelli V., Cotter R.J., and Cole P.A.
Regulation of the p300 HAT Domain via a Novel Activation
Loop. Nature Struct. & Mol. Biol. 2004; In press.
Paul
Thompson's information page
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