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 CCCR Golf Team:
(left to right)
   Shane Caldwell, David Wright, Joe North, Justin Hulme, and Frank Berger

On Saturday, August 9, the CCCR attended and sponsored a golf team at the Lori North Memorial Golf Tournament in memory of Lori, who lost her battle with colon cancer last summer.  The tournament was organized by Lori’s husband Joe North, and their daughter Hope Gold.  The CCCR team consisted of Frank Berger, Justin Hulme, and colon cancer survivors Shane Caldwell and David Wright.  One hundred and thirty golfers came out despite heavy rains to make this event a success.  Proceeds from the tournament will be donated to the CCCR and to Palmetto Animal Assisted Life Services (PAALS).

SCMission2014SCCCPN navigators promote colon cancer awareness and education at annual health event.

Hailey Hicks and Angela Ross, patient navigators for the South Carolina Colon Cancer Prevention Network (SCCCPN) ─ CCCR's colon cancer education and outreach program ─ were present at the “SC Mission 2014 Midlands” event held at the State Fairgrounds on August 8 and 9.  They provided awareness and education about colorectal cancer and the importance of screening to the attendees.  In addition, they presented information on the services that the SCCCPN furnishes to the uninsured and medically underserved citizens ─ SC Mission 2014 Midlands’ target population.

The CCCR Biorepository, under the direction of Dr. David Reisman, collects biopsy specimens from patients undergoing surgery for cancer, and makes them available to researchers.  In an effort to take full advantage of the patient materials, the Biorepository has begun mutation profiling of DNA samples from colon tumors.  In concert with Selah Genomics in Greenville, SC, the project has employed their PrecisionPathTM Next-Gen DNA sequencing technology to generate profiles of over 2,000 genomic sites spanning 52 genes known to be associated with human cancer.  Preliminary analysis of the results indicates an average of 4 gene mutations per tumor.  The p53 tumor suppressor gene, known to be defective in many human cancers, was found to be mutated in 67% of the cases.  Members of the RAS and PIK3CA families of genes, important components of cell signaling, were defective in 60% and 50% of cases, respectively.  The APC gene, known to play a role in initiating colon cancer, was mutated in 33% of cases.  The characterization of colon tumor genes in this manner is import to the determination of the underlying genetic basis of these cancers, and will be of great value to researchers trying to understand how colon cancer develops and progresses.